ABSTRACT

The aim of the present research was to find out the in vitro biological behaviour by evaluating the bioactivity of scaffolds for bone tissue engineering and to examine the mechanism of baghdadite and apatite formation. For this purpose, baghdadite scaffolds with polycaprolactone and graphene nanocomposite coatings were fabricated using polymeric sponge and dip-coating methods. Results showed that regarding baghdadite formation mechanism, gittinsite phase can be converted into baghdadite phase by enhancing temperature up to 1350°C and helping Zr⁴⁺ and Ca²⁺. The deposit of Ca–P coatings on the surface and in the pores of the scaffolds verified the improvement of the bioactivity. Graphene in scaffold composition can affect apatite deposit formation and promise bioactivity due to its high hydrophilicity, existence of nanoparticles and great $\pi$ bonds in its structure. In brief, baghdadite scaffolds with polycaprolactone and graphene nanocomposite coatings can be promising outstanding candidates for bone tissue engineering.

摘要

本研究的目的是通过评估骨组织工程支架的生物活性来了解其体外生物学行为，并研究巴格达石和磷灰石的形成机制。为此，使用聚合物海绵和浸涂方法制造了具有聚己内酯和石墨烯纳米复合涂层的巴格达石支架。结果表明，关于baghdadite形成机制，通过将温度提高到1350°C并帮助Zr ⁴⁺和Ca ²⁺可以将gittinsite相转化为baghdadite相。. Ca-P 涂层在支架表面和孔隙中的沉积证实了生物活性的提高。支架组合物中的石墨烯由于其高亲水性、纳米粒子的存在和巨大的$\pi$其结构中的键。简而言之，具有聚己内酯和石墨烯纳米复合涂层的巴格达石支架可以成为骨组织工程的杰出候选者。