ABSTRACT

Objectives

This study aims to systematically review the neurological complications in patients with SARS-CoV-2 infection and the methods used to diagnose both neurological complications and coronavirus infection.

Methods

Data from three different online databases (PubMed, Scopus and Web of Science) were searched on 29 April 2020 and after duplicate, irrelevant, and inappropriate records were excluded, data extraction was done.

Results

The 22 records included for analysis provided 57 patients with neurological sequelae. The neurological complications reported ranged widely from ischemic cerebrovascular accidents to cerebral hemorrhage and were seen at both peripheral and central nervous system levels. The most frequently reported neurological complication was acute ischemic cerebrovascular accident, followed by Guillain–Barré syndrome.

Conclusions

Considering the possibility of neurological involvement in patients with SARS-CoV-2 infection can result in earlier diagnosis and treatment; otherwise permanent, irreversible sequelae and even death may follow. More comprehensive studies may indicate that until the end of the present pandemic, young adults with unexplained and unexpected stroke as well as patients with newly diagnosed Guillain–Barré syndrome should be tested for SARS-CoV-2 infection.

中文翻译：

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COVID-19的神经系统并发症：系统评价。

摘要

目标

这项研究旨在系统地审查SARS-CoV-2感染患者的神经系统并发症以及用于诊断神经系统并发症和冠状病毒感染的方法。

方法

于2020年4月29日对来自三个不同的在线数据库（PubMed，Scopus和Web of Science）的数据进行了搜索，并在重复，无关和不适当的记录被排除后，进行了数据提取。

结果

纳入分析的22条记录为57例神经系统后遗症患者提供了帮助。报告的神经系统并发症范围广泛，从缺血性脑血管意外到脑出血，在周围和中枢神经系统水平均可见。报道最多的神经系统并发症是急性缺血性脑血管意外，其次是格林-巴利综合征。

结论

考虑到SARS-CoV-2感染患者可能会受到神经系统感染，因此可以及早诊断和治疗；否则可能会导致永久性，不可逆转的后遗症甚至死亡。更全面的研究可能表明，在当前大流行结束之前，应对原因不明和未曾预料到的中风青年以及新诊断为格林-巴利综合征的患者进行SARS-CoV-2感染检测。