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Precursors of thymic peptides as stress sensors.
Expert Opinion on Biological Therapy ( IF 4.6 ) Pub Date : 2020-08-04 , DOI: 10.1080/14712598.2020.1800636
Sergey Lunin 1 , Maxim Khrenov 1 , Olga Glushkova 1 , Svetlana Parfenyuk 1 , Tatyana Novoselova 1 , E Novoselova 1
Affiliation  

ABSTRACT

Introduction

A large volume of data indicates that the known thymic hormones, thymulin, thymopoietin, thymosin-α, thymosin-β, and thymic humoral factor-y2, exhibit different spectra of activities. Although large in volume, available data are rather fragmented, resulting in a lack of understanding of the role played by thymic hormones in immune homeostasis.

Area covered

Existing data compartmentalizes the effect of thymic peptides into 2 categories: influence on immune cells and interconnection with neuroendocrine systems. The current study draws attention to a third aspect of the thymic peptide effect that has not been clarified yet, wherein ubiquitous and highly abundant intranuclear precursors of so called ‘thymic peptides’ play a fundamental role in all somatic cells.

Expert opinion

Our analysis indicated that, under certain stress-related conditions, these precursors are cleaved to form immunologically active peptides that rapidly leave the nucleus and intracellular spaces, to send ‘distress signals’ to the immune system, thereby acting as stress sensors. We propose that these peptides may form a link between somatic cells and immune as well as neuroendocrine systems. This model may provide a better understanding of the mechanisms underlying immune homeostasis, leading thereby to the development of new therapeutic regimes utilizing the characteristics of thymic peptides.



中文翻译:

胸腺肽的前体作为压力传感器。

摘要

介绍

大量数据表明,已知的胸腺激素,胸腺素,胸腺生成素,胸腺素-α,胸腺素-β和胸腺体液因子-γ2表现出不同的活性谱。尽管数量庞大,但可用数据相当分散,导致人们对胸腺激素在免疫稳态中的作用缺乏了解。

覆盖面积

现有数据将胸腺肽的作用分为两类:对免疫细胞的影响和与神经内分泌系统的互连。当前的研究引起人们对胸腺肽作用的第三方面的关注,该方面尚未弄清,其中所谓的“胸腺肽”的普遍存在和高度丰富的核内前体在所有体细胞中都起着基本作用。

专家意见

我们的分析表明,在某些与压力相关的条件下,这些前体被裂解形成具有免疫活性的肽,这些肽会迅速离开细胞核和细胞内空间,向免疫系统发送“窘迫信号”,从而充当压力传感器。我们建议这些肽可能在体细胞与免疫系统和神经内分泌系统之间形成联系。该模型可以提供对免疫稳态基础的更好理解,从而导致开发利用胸腺肽特性的新治疗方案。

更新日期:2020-08-04
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