ABSTRACT

Resveratrol (RSV) is a natural polyphenol present in grapes, the skin of peanuts, and several other plants with many health benefits. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that may be linked to neural and synaptic development impairments. The present study aimed to analyze the preventive effects of RSV on the development of ASD-like behavior, using oxytocin receptor gene knockout (Oxtr-KO) and valproic acid-induced ASD (VPA-ASD) model mice. Genetic deficiencies in Oxtr are suggested to be involved in ASD etiology. Twenty-four hours after a single RSV injection to the Oxtr-KO mice, the social impairments caused by OXTR deficiency were ameliorated. RSV also improved social impairments in the VPA-ASD mice. Administration of RSV up-regulated silent information regulator 1 (Sirt1) gene and early growth response factor 3 (Egr3) gene expressions in the amygdala of the Oxtr-KO mice. Our data suggest that RSV may have therapeutic effects on ASD with multiple targets.

摘要

白藜芦醇（RSV）是一种天然多酚，存在于葡萄，花生皮和其他几种对健康有益的植物中。自闭症谱系障碍（ASD）是一种神经发育障碍，可能与神经和突触发育障碍有关。本研究旨在使用催产素受体基因敲除（Oxtr -KO）和丙戊酸诱导的ASD（VPA-ASD）模型小鼠来分析RSV对ASD样行为发展的预防作用。提示Oxtr的遗传缺陷与ASD病因有关。向Oxtr注射一次RSV后的二十四小时-KO小鼠，由OXTR缺乏引起的社会障碍得到改善。RSV还改善了VPA-ASD小鼠的社交障碍。RSV的上调在Oxtr -KO小鼠的杏仁核中沉默信息调节因子1（Sirt1）基因和早期生长反应因子3（Egr3）基因表达的管理。我们的数据表明，RSV可能对具有多个靶标的ASD具有治疗作用。