Background: In Uganda, national tuberculosis (TB) treatment guidelines were revised to include the newer generation fluoroquinolones among the second-line treatment options for multidrug-resistant TB. This study was designed to analyze if the prescription of these quinolones is compliant with country recommendations. Methods: This was an observational retrospective study of consumption data for 2017 and 2018 across four selected regional referral hospitals. The sources of consumption data were hospital pharmacy stock cards and the dispensing register. The medical files of patients who had been prescribed fluoroquinolones were also assessed to study compliance with the Uganda Clinical Guidelines and the British National Formulary (BNF). Results: None of the 371 levofloxacin prescriptions analyzed complied with the Uganda Clinical Guidelines, although 250 (67.3%) were prescribed for indications included in the BNF. According to WHO prescription indicators, only 220 (59.3%) prescriptions were appropriate. Conclusion: The prescription of levofloxacin and moxifloxacin increased in the hospitals studied, but in a high proportion of cases, they were not compliant with country recommendations. The findings call for the strengthening of national antimicrobial stewardship programs.

中文翻译：

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乌干达部分医院的左氧氟沙星和莫西沙星处方：评估指南一致性的初步研究。

背景：在乌干达，修订了国家结核病治疗指南，将新一代的氟喹诺酮类药物纳入耐多药结核病的二线治疗方案。本研究旨在分析这些喹诺酮类药物的处方是否符合国家/地区的建议。方法：这是一项观察性回顾性研究，研究了四家选定地区转诊医院2017年和2018年的消费数据。消费数据的来源是医院药房存货卡和配药登记册。还对服用氟喹诺酮类药物的患者的医疗档案进行了评估，以研究其对乌干达临床指南和英国国家配方（BNF）的依从性。结果：分析的371份左氧氟沙星处方均未符合《乌干达临床指南》，尽管BNF所含适应症的处方为250份（占67.3％）。根据WHO的处方指标，仅220份（59.3％）处方是合适的。结论：所研究的医院中左氧氟沙星和莫西沙星的处方增加，但在大多数情况下，它们不符合国家建议。调查结果要求加强国家抗菌素管理计划。