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Natural Killer cell-derived extracellular vesicles in cancer therapy.
Scandinavian Journal of Immunology ( IF 3.7 ) Pub Date : 2020-07-22 , DOI: 10.1111/sji.12938
Marius Farcas 1 , Marit Inngjerdingen 1
Affiliation  

Cancer is a major cause of death in the industrialized world. New therapies are constantly being developed in order to reduce morbidity and mortality. NK cell–based cellular therapies have shown effect against haematological malignancies, but it has been difficult to target solid tumours due to low NK cell infiltration of the tumour and efficient tumour evasion strategies. NK cells release extracellular vesicles that naturally contain cytolytic proteins and tumour‐targeting molecules. These vesicles can directly interact with and kill malignant cells, and their small size could allow more efficient extravasation into the tumour tissue. Extracellular vesicles are also less sensitive to the hostile tumour microenvironment compared to cells. Based on their features, NK cell–derived extracellular vesicles represent promising novel tools in oncology. In this review, we summarize the current available literature on NK cell–derived extracellular vesicles and discuss how they may be utilized in therapy for solid tumours.

中文翻译:

天然杀伤细胞衍生的细胞外囊泡在癌症治疗中的作用。

癌症是工业化世界中的主要死亡原因。为了减少发病率和死亡率,不断开发新的疗法。基于NK细胞的细胞疗法已显示出对血液恶性肿瘤的作用,但由于NK细胞对肿瘤的低浸润和有效的肿瘤规避策略,很难靶向实体瘤。NK细胞释放天然含有溶细胞蛋白和肿瘤靶向分子的细胞外囊泡。这些囊泡可以直接与恶性细胞相互作用并杀死恶性细胞,它们的小尺寸可以使其更有效地渗入肿瘤组织。与细胞相比,细胞外囊泡对敌对肿瘤微环境的敏感性也较低。基于它们的特征,源自NK细胞的细胞外囊泡代表了有前途的肿瘤学新工具。
更新日期:2020-09-30
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