Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.,Molecular Genetics & Genomic Medicine

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Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.
Molecular Genetics & Genomic Medicine ( IF 2 ) Pub Date : 2020-07-23 , DOI: 10.1002/mgg3.1319
Mohamed A Ismail _{1,

2} , Muthanna Samara ₃ , Ali Al Sayab ₂ , Mohamed Alsharshani ₄ , Mohamed A Yassin ₅ , Govindarajulu Varadharaj ₆ , Marzia Vezzalini ₇ , Luisa Tomasello ₈ , Maria Monne ₉ , Hisham Morsi ₁₀ , M Walid Qoronfleh ₁₁ , Hatem Zayed ₁₂ , Richard Cook ₁ , Claudio Sorio ₇ , Helmout Modjtahedi ₁ , Nader I Al-Dewik _{1,

13,

14,

15}

Affiliation

School of Life Science, Pharmacy and Chemistry, Faculty of Science, Engineering & ComputingFaculty of Science, Engineering & Computing, Kingston University London, Kingston-Upon-Thames, UK.
Interim Translational Research Institute (iTRI), Hamad Medical Corporation (HMC), Doha, Qatar.
Department of Psychology, Kingston University London, Kingston upon Thames, London, UK.
Diagnostic Genetics Division (DGD), Department of Laboratory Medicine and Pathology (DLMP), Hamad Medical Corporation (HMC), Doha, Qatar.
Department of Medical Oncology, National Centre for Cancer Care and Research, Hamad Medical Corporation (HMC), Doha, Qatar.
Genetrics Inc, Dubai, United Arab Emirates.
General Pathology Division, Department of Medicine, University of Verona, Verona, Italy.
Wexner Medical Center, Biomedical Research Tower, The Ohio State University, Columbus, OH, USA.
Centro di Diagnostica Biomolecolare e Citogenetica Emato-Oncologica, San Francesco" Hospital, Nuoro, Italy.
Quality of Life unit, National Center for Cancer Care and Research, (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
World Innovation Summit for Healthcare (WISH), Qatar Foundation, Doha, Qatar.
Department of Biomedical Sciences, Biomedical Research Center, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Qatar Medical Genetic Center (QMGC), Hamad General Hospital (HGH), and Interim Translational Research Institute (iTRI), Hamad Medical Corporation (HMC), Doha, Qatar.
College of Health and Life Science (CHLS), Hamad Bin Khalifa University (HBKU), Doha, Qatar.
Department of Pediatrics, Women's Wellness and Research Center (WWRC), HMC, Doha, Qatar.

Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated in chronic myeloid leukemia (CML) disease. The mechanism behind its downregulation has not been fully elucidated yet.

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