Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis.,European Journal of Neurology

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Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis.
European Journal of Neurology ( IF 5.1 ) Pub Date : 2020-07-22 , DOI: 10.1111/ene.14447
A H Katsanos _{1,

2} , A V Alexandrov ₃ , P Mandava _{4,

5} , M Köhrmann ₆ , L Soinne ₇ , A D Barreto ₈ , V K Sharma ₉ , R Mikulik ₁₀ , K W Muir ₁₁ , T Rothlisberger ₁₂ , J C Grotta ₁₃ , C R Levi ₁₄ , C A Molina ₁₅ , M Saqqur _{16,

17} , L Palaiodimou ₂ , T Psaltopoulou ₁₈ , M R Vosko ₁₉ , T Moreira ₂₀ , J B Fiebach ₂₁ , M Rubiera ₁₅ , E C Sandset ₂₂ , A de Havenon ₂₃ , T A Kent _{24,

25} , A W Alexandrov ₃ , P D Schellinger ₂₆ , G Tsivgoulis _{2,

3} ,

Affiliation

Division of Neurology, McMaster University/Population Health Research Institute, Hamilton, ON, Canada.
Second Department of Neurology, 'Attikon' University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
Stroke Outcomes Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Michael E. DeBakey VA Medical Center Stroke Program and Center for Translational Research on Inflammatory Diseases, Houston, TX, USA.
Department of Neurology, University Hospital Essen, Essen, Germany.
Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, University of Helsinki, Helsinki, Finland.
Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and Division of Neurology, National University Hospital, Singapore, Singapore.
International Clinical Research Centre and Department of Neurology, St Anne's University Hospital in Brno and Medical Faculty, Masaryk University, Brno, Czech Republic.
Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.
Cerevast Medical Inc., Bothell, WA, USA.
Clinical Innovation and Research Institute, Memorial Hermann Hospital-Texas Medical Center, Houston, TX, USA.
Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia.
Stroke Unit, Department of Neurology, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain.
Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada.
Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Department of Hygiene, Epidemiology, and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Neurology 2, Med Campus III, Kepler University Hospital, Linz, Austria.
Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
Center for Stroke Research Berlin, Charité-University Medicine Berlin, Berlin, Germany.
Department of Neurology, Stroke Unit, Oslo University Hospital, Oslo, Norway.
Department of Neurology, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA.
Texas A&M Health Science Center-Houston campus, University of Texas, Houston, TX, USA.
Department of Neurology, Houston Methodist Hospital, Houston, TX, USA.
Departments of Neurology and Neurogeriatry, John Wesling Medical Center Minden, Ruhr University Bochum, Minden, Germany.

Blood pressure (BP) variability has been associated with worse neurological outcomes in acute ischaemic stroke (AIS) patients receiving treatment with intravenous thrombolysis (IVT). However, no study to date has investigated whether pulse pressure (PP) variability may be a superior indicator of the total cardiovascular risk, as measured by clinical outcomes.

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