The non-therapeutic use of the androgenic anabolic steroid Nandrolone Decanoate is popular due to its effects on physical performance and body composition, especially for its lipolytic and anabolic effects associated. However, high doses of such drugs are often associated with a series of pathologies related to unbalanced redox homeostasis, which, in turn, can be linked to inflammation. The oxidative stress onset could deregulate the secretion of cytokines, evidencing a dysfunctional adipocyte. Thus, the aim of this study was to investigate the effect of supraphysiological doses of Nandrolone Decanoate on redox homeostasis of retroperitoneal fatpad of male rats and its relationship with cytokines-based inflammatory signaling. Hydrogen peroxide production was assessed in the retroperitoneal fat pad of adult male rats which received either 10 mg kg of Nandrolone Decanoate or only a vehicle. Also, catalase, superoxide dismutase and glutathione peroxidase activities were measured, together with total reduced thiols and protein carbonylation, as well as IL-1β, TNF-α, and IL-6 local levels. High doses of Nandrolone Decanoate caused an increase in the hydrogen peroxide production, together with lower activities of the antioxidant enzymes and lower levels of total reduced thiol. There were also higher protein carbonylation and greater levels of IL-1β, TNF-α, and IL-6 in the treated group compared to control group. Therefore, it was possible to verify that high doses of Nandrolone Decanoate cause oxidative stress and induce higher inflammatory signaling in retroperitoneal fat pad of male rats.

雄激素合成代谢类固醇癸酸诺龙的非治疗用途由于其对身体机能和身体成分的影响而广受欢迎，尤其是其相关的脂解和合成代谢作用。但是，高剂量的这类药物通常与一系列与氧化还原稳态失衡有关的病理有关，而氧化还原稳态又可能与炎症有关。氧化应激的发作可能会调节细胞因子的分泌，从而证明脂肪细胞功能异常。因此，本研究的目的是研究超生理剂量癸酸诺龙对雄性大鼠腹膜后脂肪垫氧化还原稳态的影响及其与基于细胞因子的炎症信号的关系。在成年雄性大鼠腹膜后脂肪垫中评估过氧化氢的产生，成年雄性大鼠接受10 mg / kg癸酸诺龙或仅添加一种媒介。此外，还测定了过氧化氢酶，超氧化物歧化酶和谷胱甘肽过氧化物酶的活性，以及​​总降低的硫醇和蛋白质羰基化以及IL-1β，TNF-α和IL-6局部水平。高剂量癸酸诺龙可以增加过氧化氢的产生，同时降低抗氧化酶的活性和降低总的巯基含量。与对照组相比，治疗组的蛋白质羰基化程度更高，IL-1β，TNF-α和IL-6的含量更高。因此，