Tetralogy of Fallot is the most common cyanotic congenital disease, affecting 10% of children with congenital heart disease. The surgical management of patients with Tetralogy of Fallot leads, however, to significant detrimental effects on the right ventricle including pulmonary valve regurgitation. This experiment aimed to simulate different cases of pulmonary valve regurgitation with varying degrees of severity in order to observe the changes in flow structures present in the right ventricle. Planar time-resolved particle image velocimetry measurements have been performed on a custom-made double activation simulator reproducing flow conditions in a model of a right ventricle. Changes in flow characteristics in the right ventricle have been evaluated in terms of velocity fields and profiles, tricuspid inflow jet orientation and viscous energy dissipation. Our results show that pulmonary valve regurgitation significantly alters the flow in the right ventricle mostly by impairing the diastolic inflow through the tricuspid valve and by increasing viscous energy loss. This fundamental work should allow for a better understanding of such changes in the RV flow dynamics. It may also help in developing new strategies allowing for a better follow-up of patients with repaired TOF and for decision-making in terms of pulmonary valve replacement.

法洛四联症是最常见的紫绀型先天性疾病，影响 10% 的先天性心脏病儿童。然而，法洛四联症患者的手术治疗会导致对右心室的显着不利影响，包括肺动脉瓣关闭不全。本实验旨在模拟不同严重程度的肺动脉瓣反流病例，以观察右心室血流结构的变化。平面时间分辨粒子图像测速测量已在定制的双激活模拟器上进行，再现了右心室模型中的流动条件。已根据速度场和剖面评估了右心室血流特征的变化，三尖瓣流入射流方向和粘性能量耗散。我们的结果表明，肺动脉瓣反流主要通过损害通过三尖瓣的舒张流入和增加粘性能量损失来显着改变右心室的血流。这项基础工作应该可以更好地了解 RV 流动力学的此类变化。它还可能有助于开发新策略，以便更好地跟踪 TOF 修复后的患者并在肺动脉瓣置换术方面做出决策。这项基础工作应该可以更好地了解 RV 流动力学的此类变化。它还可能有助于开发新策略，以便更好地跟踪 TOF 修复后的患者并在肺动脉瓣置换术方面做出决策。这项基础工作应该可以更好地了解 RV 流动力学的此类变化。它还可能有助于开发新策略，以便更好地跟踪 TOF 修复后的患者并在肺动脉瓣置换术方面做出决策。