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KUSA-A1 mesenchymal stem cells response to PEEK-Si3N4 composites
Materials Today Chemistry ( IF 7.3 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.mtchem.2020.100316
E. Marin , F. Boschetto , M. Zanocco , T. Adachi , N. Toyama , W. Zhu , B.J. McEntire , R.M. Bock , B.S. Bal , G. Pezzotti

Abstract Poly-Ether-Ether-Ketone (PEEK) is a structural biopolymer with various biomedical applications, from spinal cages to dental prosthetics. Due its high chemical stability combined with good mechanical strength, PEEK is considered to be one of the most successful bio-inert polymers ever developed. In this work, a mixture of PEEK and β-Si3N4 was used to produce a composite material which combined the mechanical properties of the polymer with the bioactive effects of a reinforcing ceramic, in particular its good osteoconductivity. When tested with KUSA-A1 mesenchymal cells, the composite material resulted in a higher production of bone tissue when compared to standard PEEK or biomedical titanium alloy. On the other hand, the composite showed poor osteogenic differentiation as evaluated by ALP. Tests performed using various spectroscopic techniques showed that the bone tissue formed has a balanced mineral-to-matrix ratio, similar to that of healthy bone tissue.

中文翻译:

KUSA-A1 间充质干细胞对 PEEK-Si3N4 复合材料的反应

摘要 聚醚醚酮 (PEEK) 是一种结构生物聚合物,具有多种生物医学应用,从脊柱笼到假牙。由于其高化学稳定性和良好的机械强度,PEEK 被认为是有史以来最成功的生物惰性聚合物之一。在这项工作中,PEEK 和 β-Si3N4 的混合物被用来生产一种复合材料,该材料将聚合物的机械性能与增强陶瓷的生物活性作用相结合,特别是其良好的骨传导性。当使用 KUSA-A1 间充质细胞进行测试时,与标准 PEEK 或生物医学钛合金相比,该复合材料可产生更高的骨组织产量。另一方面,通过 ALP 评估,复合材料显示出较差的成骨分化。
更新日期:2020-09-01
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