In this study, sulfonate functionalized N-heterocyclic carbene ligand precursors were obtained from the compounds 1-alkylbenzimidazole, 1,3-propane sultone, and 1,4-butane sultone. These NHC ligand precursors were metallated with Ag₂O on moderate conditions to give novel silver-NHC complexes. All new compounds were characterized by by ¹H NMR, ¹³C NMR, FT-IR and elemental analysis techniques. The cytotoxic properties of the silver(I) complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC₅₀ values of these four complexes were determined by the MTT based assay on three human cell lines brain (SHSY5Y) and liver (HEP3B). These silver N-heterocyclic carbene complexes have been highlighted metal-based cancer therapeutic agents with unique structures and functions. These strategies provide exciting opportunities for discovering new types of metallodrugs.

在这项研究中，磺酸盐官能化的N-杂环卡宾配体前体是从化合物1-烷基苯并咪唑，1,3-丙烷磺酸内酯和1,4-丁烷磺酸内酯获得的。将这些NHC配体前体在中等条件下用Ag ₂ O金属化，得到新颖的银-NHC络合物。所有新化合物均通过¹ H NMR，¹³ C NMR，FT-IR和元素分析技术表征。已经在包括顺铂敏感和耐药细胞在内的各种人类癌症细胞系中评估了银（I）配合物的细胞毒性。这四种复合物的IC ₅₀值是通过基于MTT的测定法在三种人类细胞系大脑（SHSY5Y）和肝脏（HEP3B）上测定的。这些银N杂环卡宾配合物已成为具有独特结构和功能的基于金属的癌症治疗剂。这些策略为发现新型金属药物提供了令人兴奋的机会。