Squamous cell carcinoma (SCC) is a frequent malignant neoplasm of the skin that usually arises from areas of solar dermatosis. It is characterized by local invasiveness and regional lymph node metastasis, mainly in poorly differentiated tumours. Galectin-3 (Gal-3) is a lectin that is expressed in the nucleus or cytoplasm and has been identified as a prognostic tool for human neoplasms. The purpose of this study was to characterize Gal-3 expression in canine cutaneous SCCs and to investigate its relationship with tumour differentiation and cell proliferation indices. Immunohistochemical analysis of 50 SCCs for Gal-3 revealed no correlation between the localization or intensity of immunolabelling, or number of immunopositive cells, with histological grade of tumour or proliferative activity. The results suggest that Gal-3 expression is not a reliable prognostic marker for cutaneous SCC in dogs.

鳞状细胞癌（SCC）是一种常见的皮肤恶性肿瘤，通常起源于日光性皮肤病。它的特点是局部浸润和局部淋巴结转移，主要发生在分化较差的肿瘤中。Galectin-3（Gal-3）是一种在细胞核或细胞质中表达的凝集​​素，已被鉴定为人类肿瘤的预后工具。这项研究的目的是表征犬皮肤SCC中Gal-3的表达，并研究其与肿瘤分化和细胞增殖指数的关系。对50个SCC的Gal-3进行的免疫组织化学分析显示，免疫标记的定位或强度，免疫阳性细胞的数量与肿瘤的组织学等级或增殖活性之间没有相关性。