OBJECTIVE Aside from the cognitive impairment, patients with dementia with Lewy bodies (DLB) have a high frequency of visual hallucinations and a number of other vision-related symptoms, whereas auditory hallucinations are less frequent. To better understand the differential dysfunction of the visual network in DLB, we compared auditory and visual event-related potentials and oscillations in patients with DLB. METHODS Event-related potentials elicited by visual and auditory oddball tasks were recorded in 23 patients with DLB and 22 healthy controls and analyzed in time and time-frequency domain. RESULTS DLB patients had decreased theta band activity related to both early sensory and later cognitive processing in the visual, but not in the auditory task. Patients had lower delta and higher alpha and beta bands power related to later cognitive processing in both auditory and visual tasks. CONCLUSIONS In DLB visual event-related oscillations are characterized by a decrease in theta and lack of inhibition in alpha bands. SIGNIFICANCE Decreased theta and a lack of inhibition in alpha band power might be an oscillatory underpinning of some classical DLB symptoms such as fluctuations in attention and high-level visual disturbances and a potential marker of dysfunction of the visual system in DLB.

中文翻译：

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路易体痴呆患者视觉和听觉事件相关振荡的差异变化

目的除了认知障碍之外，路易体痴呆 (DLB) 患者出现幻视和许多其他视觉相关症状的频率很高，而幻听的频率较低。为了更好地了解 DLB 中视觉网络的不同功能障碍，我们比较了 DLB 患者的听觉和视觉事件相关电位和振荡。方法 记录 23 名 DLB 患者和 22 名健康对照组由视觉和听觉奇怪任务引起的事件相关电位，并在时域和时频域中进行分析。结果 DLB 患者减少了与视觉中早期感觉和后期认知处理相关的 theta 带活动，但在听觉任务中没有。患者在听觉和视觉任务中具有与后期认知处理相关的较低 delta 和较高的 alpha 和 beta 波段功率。结论 在 DLB 中，与视觉事件相关的振荡的特征在于θ 的降低和 α 波段的抑制缺乏。意义 θ 降低和 α 波段能量缺乏抑制可能是一些经典 DLB 症状的振荡基础，例如注意力波动和高水平视觉障碍，以及 DLB 视觉系统功能障碍的潜在标志。