OBJECTIVE This study aimed to investigate the differential effects of bilateral and unilateral mirror therapy (MT) on motor cortical activations in stroke patients by magnetoencephalography (MEG). METHODS Sixteen stroke patients and 16 right-handed healthy volunteers were recruited. All participants were required to perform 4 conditions: resting, no mirror with bilateral hand movements (Bilateral-No mirror), mirror with bilateral hand movements (Bilateral-Mirror) and mirror with unilateral hand movements (Unilateral-Mirror). Beta oscillatory activities in the primary motor cortex (M1) were collected during each condition using MEG. The percentage change of beta oscillatory activity was calculated for each condition to correct the baseline differences. RESULTS In the stroke group, the percentage change of M1 beta oscillatory activity significantly decreased more in the Bilateral-Mirror condition than in the Bilateral-No mirror and Unilateral-Mirror conditions. In the healthy group, no significant differences in the percentage change of beta oscillatory activity were found among the 3 conditions. Further, a significant difference in the percentage change of beta oscillatory activity only in the Bilateral-Mirror condition was found between the 2 groups. CONCLUSIONS This study provides new information on the differential cortical activations modulated by bilateral and unilateral MT. SIGNIFICANCE Bilateral MT led to greater M1 neural activities than unilateral MT and bilateral movements without a mirror in stroke patients.

中文翻译：

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中风后双侧和单侧镜疗法诱发的皮质神经活动

目的 本研究旨在通过脑磁图 (MEG) 研究双侧和单侧镜像疗法 (MT) 对中风患者运动皮层激活的不同影响。方法 招募了 16 名中风患者和 16 名右手健康志愿者。所有参与者都被要求执行 4 个条件：休息、没有双侧手部运动的镜子（Bilateral-No mirror）、双侧手部运动的镜子（Bilateral-Mirror）和单侧手部运动的镜子（Unilateral-Mirror）。在每个条件下使用 MEG 收集初级运动皮层 (M1) 中的 Beta 振荡活动。计算每个条件的 β 振荡活动的百分比变化以校正基线差异。结果 在卒中组中，在双边镜条件下，M1 beta 振荡活动的百分比变化比双边无镜和单边镜条件下显着降低。在健康组中，在 3 种条件下，β 振荡活动的百分比变化没有显着差异。此外，发现两组之间仅在双边镜条件下β振荡活动的百分比变化存在显着差异。结论 这项研究提供了关于由双侧和单侧 MT 调节的不同皮质激活的新信息。意义 在中风患者中，双侧 MT 比单侧 MT 和双侧运动导致更大的 M1 神经活动。