Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed “membrane contact sites” (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment.

真核细胞中的膜结合细胞器形成一个交互网络来协调和促进细胞功能。紧密接触的形成，称为“膜接触位点”（MCS），代表了一种有趣的细胞器相互作用和协调相互作用的策略。新兴研究正在迅速揭示 MCS 的新细节。它们代表了无处不在和多样化的结构，这对于细胞生理学和体内平衡的许多方面都很重要。在这里，我们全面概述了细胞器接触的生理相关性。我们专注于线粒体、过氧化物酶体、高尔基复合体和质膜，并讨论它们与其他亚细胞器的相互作用及其多种功能的最新发现，包括与 ER 的膜接触，