Lasso peptides produced by bacteria have a very unique cyclic structure (“lasso” structure) and are resistant to protease. To date, a number of lasso peptides have been isolated from proteobacteria and actinobacteria. Many lasso peptides exhibit various biological activities, such as antibacterial activity, and are expected to have various applications. Based on study of genome mining, large numbers of biosynthetic gene cluster of lasso peptides are revealed to distribute over genomes of proteobacteria and actinobacteria. However, the biosynthetic gene clusters are cryptic in most cases. Therefore, the combination of genome mining and heterologous production is efficient method for the production of lasso peptides. To utilize lasso peptide as fine chemical, there have been several attempts to add new function to lasso peptide by genetic engineering. Currently, a more efficient lasso peptide production system is being developed to harness cryptic biosynthetic gene clusters of lasso peptide. In this review, the overview of lasso peptide study is discussed.

细菌产生的套索肽具有非常独特的环状结构（“套索”结构），并且对蛋白酶具有抗性。迄今为止，已经从变形杆菌和放线菌中分离出许多套索肽。许多套索肽表现出各种生物活性，例如抗菌活性，并有望具有各种应用。基于对基因组挖掘的研究，发现套索肽的大量生物合成基因簇分布在变形杆菌和放线菌的基因组上。然而，在大多数情况下，生物合成基因簇是隐性的。因此，将基因组挖掘和异源生产相结合是生产套索肽的有效方法。为了将套索肽用作精细化学品，已经有几种尝试通过基因工程为套索肽增加新功能。当前，正在开发更有效的套索肽生产系统以利用套索肽的隐密生物合成基因簇。在这篇综述中，讨论了套索肽研究的概述。