An automated flow platform based on a tube-in-tube contactor and micro-packed bed reactor is developed to measure the kinetics of gas–liquid–solid hydrogenation reactions. The liquid flowing in the inner tube of the tube-in-tube contactor is rapidly saturated to ensure a constant H₂ concentration before entering the micro-packed bed, which transforms the gas–liquid–solid system into a liquid–solid system. A ramping strategy is adopted in which the continuously varied residence time and the corresponding conversion data are obtained in a single experiment. Two reactions including hydrogenation of α-methylstyrene and nitrobenzene are chosen to demonstrate the accuracy and efficiency of this automated platform. Varying the flow rate ramping shows that accurate kinetic determination requires a specific range of flow rate ramps. A kinetic curve of conversion versus residence time (more than ten thousand data points) can be obtained in a single experiment within 50 min. The kinetic parameters obtained with this strategy agree well with literature values. The automated flow platform with flow rate ramping enables accurate determination of gas–liquid–solid reaction kinetics with higher efficiency and lower reagent cost compared with other methods.

中文翻译：

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一个自动确定气体-液体-固体反应动力学的流动平台

开发了基于管内接触器和微填充床反应器的自动化流动平台，以测量气-液-固加氢反应的动力学。管内接触器内管中流动的液体迅速饱和，以确保恒定的H ₂进入微填充床之前的浓缩，将气液固系统转变为液固系统。采用渐变策略，其中在单个实验中获得连续变化的停留时间和相应的转换数据。选择了两个反应，包括氢化α-甲基苯乙烯和硝基苯，以证明该自动化平台的准确性和效率。改变流量斜率表明准确的动力学确定需要特定范围的流量斜率。转化动力学曲线与一次实验可在50分钟内获得停留时间（超过一万个数据点）。用该策略获得的动力学参数与文献值非常吻合。与其他方法相比，具有流速递增功能的自动流动平台能够以更高的效率和更低的试剂成本准确确定气-液-固反应动力学。