A new neo-lignan named (7ʹS,8ʹR)-4ʹ,5ʹ,9ʹ-trihydroxy-5-methoxy-4,8ʹ-oxyneolign-7-en-9-al (1), together with 5 known compounds (2-6) were isolated from the ethylacetate-soluble extract of Acanthopanax senticosus. The structure of new neo-lignan was elucidated with spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro cytotoxicity against 4 human cancer lines including HepG2, A549, Hela, and MCF-7. Among them, compounds 1 and 3 showed the potent antiproliferative activities against the HepG2 cancer cells with half-maximal inhibitory concentration (IC₅₀) values of 9.8 ± 1.6 and 15.0 ± 1.1 μM, respectively. In addition, compound 6 exhibited moderate inhibitory activity on MCF-7 cancer cells with an IC₅₀ value of 18.3 ± 1.5 μM.

命名为（7'-一个新的新木脂素小号，8'- - [R）-4'-，5'-，9'-三羟基-5-甲氧基- 4,8'-oxyneolign -7-烯-9-人，（1）中，用5种已知化合物一起（2 - 6）从的乙酸乙酯可溶性提取物中分离刺五加。通过光谱学和理化分析阐明了新的新木脂素的结构。评估了所有分离株对包括HepG2，A549，Hela和MCF-7在内的4种人类癌症株的体外细胞毒性。其中，化合物1和3对HepG2癌细胞显示出有效的抗增殖活性，抑制浓度为一半（IC ₅₀）分别为9.8±1.6和15.0±1.1μM。此外，化合物6对MCF-7癌细胞表现出中等抑制活性，IC ₅₀值为18.3±1.5μM。