Abstract

Wild-type p53-induced phosphatase 1 (WIP1) belongs to the protein phosphatase 2C (PP2C) family and is a mammalian serine/threonine specific protein phosphatase to dephosphorylate numerous signaling molecules. Mammalian WIP1 regulates a wide array of targeting molecules and plays key regulatory roles in many cell processes such as DNA damage and repair, cell proliferation, differentiation, apoptosis, and senescence. WIP1 promotes the formation and development of tumors as an oncogene and a negative regulator of p53. It is also involved in the regulation of aging, neurological diseases and immune diseases. Recent studies demonstrated the critical roles of WIP1 in the differentiation and function of immune cells including T cells, neutrophils and macrophages. In the present manuscript, we briefly summarized the expression patterns, biological function and the target molecules and signal pathways of WIP1 and mainly discussed the latest advances on the regulatory effects of WIP1 in the immune system. WIP1 may be a potential target molecule to treat cancers and immune diseases such as allergic asthma.

摘要

野生型 p53 诱导的磷酸酶 1 (WIP1) 属于蛋白磷酸酶 2C (PP2C) 家族，是一种哺乳动物丝氨酸/苏氨酸特异性蛋白磷酸酶，可对众多信号分子进行去磷酸化。哺乳动物 WIP1 调节多种靶向分子，并在许多细胞过程中发挥关键调节作用，如 DNA 损伤和修复、细胞增殖、分化、凋亡和衰老。WIP1 作为癌基因和 p53 的负调节因子促进肿瘤的形成和发展。它还参与调节衰老、神经系统疾病和免疫疾病。最近的研究证明了 WIP1 在免疫细胞（包括 T 细胞、中性粒细胞和巨噬细胞）的分化和功能中的关键作用。在本手稿中，我们简要总结了表达模式，WIP1 的生物学功能和靶分子和信号通路，主要讨论 WIP1 在免疫系统中的调节作用的最新进展。WIP1可能是治疗癌症和过敏性哮喘等免疫疾病的潜在靶分子。