The main reason for root canal treatment failure is the persistence of microorganisms after therapy, or the recontamination of the root canal system due to an inadequate seal. In the mouth, Actinomyces spp. constitute a significant part of the normal flora, which is indicative of their ability to adhere to oral tissue and resist cleansing mechanisms, such as salivary flow. This review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), aims to clarify the prevalence of microbial genera that are associated with the genus Actinomyces in primary and secondary endodontic infections (primary outcome), and to identify the most prevalent species of the Actinomyces genus in endodontic lesions (secondary outcome). A total of 11 studies were included in the qualitative and quantitative analysis, and a total of 331 samples were analyzed. Bacteria of the genus Actinomyces were found in 58 samples, and 46 bacterial genera were detected in association with bacteria of the genus Actinomyces. Bacteria of the genus Streptococcus and Propionibacterium were those most frequently associated with Actinomyces in the endodontic lesions considered, and Actinomyces israelii was the most frequently involved species.

中文翻译：

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原发性和继发性牙髓病变中微生物与放线菌属的关联，综述。

根管治疗失败的主要原因是治疗后微生物的持续存在，或者由于密封不充分而导致根管系统的再次污染。在口腔中，放线菌属。构成正常菌群的重要组成部分，这表明它们粘附口腔组织并抵抗唾液流等清洁机制的能力。本综述根据系统评价和荟萃分析的首选报告项目 (PRISMA) 进行，旨在澄清原发性和继发性牙髓感染中与放线菌属相关的微生物属的流行率（主要结果），并确定牙髓病变中最常见的放线菌属物种（次要结果）。共纳入11项研究进行定性和定量分析，共分析331个样本。在58个样品中发现了放线菌属细菌，并检测到了46个与放线菌属细菌相关的细菌属。在所考虑的牙髓病变中，链球菌属和丙酸杆菌属细菌是最常与放线菌相关的细菌，而以色列放线菌是最常涉及的物种。