In the present study, the impact of a combination of four memory‐enhancer herbs on cognitive impairment and brain tissue oxidative damage due to hypothyroidism was evaluated. Propylthiouracil (PTU; 0.05%) was administrated in drinking water. Rats were treated with a combination of four herbal products (Cyperus rotundus, Crocus sativus, Piper nigrum, and Boswellia serrata) mixed with honey at two doses (640 and 1,280 mg/kg) or donepezil (0.5 mg/kg), for 6 weeks. Memory performance on the Morris water maze (MWM) and avoidance behavior in passive avoidance was impaired by hypothyroidism, and brain tissue oxidative damage occurred. Herbal combination and donepezil significantly improved memory impairment, reduced malondialdehyde concentration, and nitric oxide metabolites while increased the thiol contents and catalase and superoxide dismutase enzymes activity in the brain. Our findings suggest that the mixture of herbal products improves learning and memory deficits caused by hypothyroidism, probably by reducing the brain tissue oxidative damage.

中文翻译：

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香附子，番红花，黑胡椒和锯缘乳香的组合对甲状腺功能低下大鼠学习记忆障碍和脑组织氧化损伤的影响。

在本研究中，评估了四种记忆增强药组合对甲状腺功能减退所致认知障碍和脑组织氧化损伤的影响。在饮用水中施用丙硫氧嘧啶（PTU； 0.05％）。用四种草药产品（圆形莎草，番红花，黑胡椒和锯齿乳香）对大鼠进行治疗）与蜂蜜以两种剂量（640和1,280 mg / kg）或多奈哌齐（0.5 mg / kg）混合，持续6周。甲状腺功能减退会损害Morris水迷宫（MWM）的记忆性能和被动回避中的回避行为，并且会发生脑组织氧化损伤。中草药联合用药和多奈哌齐可显着改善记忆障碍，降低丙二醛浓度和一氧化氮代谢产物，同时增加脑中硫醇含量以及过氧化氢酶和超氧化物歧化酶的活性。我们的研究结果表明，草药产品的混合物可通过减少脑组织氧化损伤来改善甲状腺功能减退症引起的学习和记忆障碍。