PIWI-interacting RNAs (piRNAs) are a kind of non-coding small RNAs, which play a biological role by specifically binding to PIWI proteins. Studies have demonstrated that piRNAs play a significant role in germline cell growth by repressing transposable elements, especially in the regulation of DNA methylation. Recently increasing evidence revealed that piRNAs involved in the regulation of cell proliferation, apoptosis, and cycle; however, the mechanism of piRNAs is unclear. This review summarizes the research progress regarding the roles of piRNAs in the cell proliferation, apoptosis, and cycle.

中文翻译：

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PIWI 相互作用的 RNA 对细胞存活的作用：增殖、凋亡和循环

PIWI-interacting RNAs (piRNAs)是一种非编码小RNA，通过与PIWI蛋白特异性结合而发挥生物学作用。研究表明，piRNAs 通过抑制转座因子在生殖细胞生长中发挥重要作用，尤其是在 DNA 甲基化的调控中。最近越来越多的证据表明piRNAs参与了细胞增殖、凋亡和周期的调节；然而，piRNAs的机制尚不清楚。本文综述了piRNA在细胞增殖、凋亡和周期中作用的研究进展。