With much interest we read the article by Wagner et al.,¹ however, their claim that “patients with breakthrough tick‐borne encephalitis suffer a more severe clinical course” is not supported by their data as the scientific evidence necessary to substantiate this claim would generally be a double‐blind randomized study, not a retrospective case series from a tertiary care center. Specifically:

中文翻译：

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读者回应：突破性蜱传脑炎患者的临床病程更严重，并表现出广泛的 MRI 改变

我们怀着极大的兴趣阅读了 Wagner 等人的文章，¹然而，他们声称“患有突破性蜱传脑炎的患者会遭受更严重的临床病程”并没有得到他们的数据的支持，因为证实这一说法所必需的科学证据将通常是一项双盲随机研究，而不是来自三级医疗中心的回顾性病例系列。具体来说：