Five undescribed 12-membered macrolides containing thioethers, thiocladospolides F-J, together with the known biogenetic related analogues, were isolated from a mangrove-derived endophytic fungus Cladosporium oxysporum. The absolute configuration of thiocladospolide F was deduced by single-crystal X-ray diffraction, and those of thiocladospolides G-J were determined based on specific optical rotation and electronic circular dichroism (ECD) data, as well as the biogenetic considerations. Thiocladospolide G display the best antimicrobial activity against the aquatic pathogen Edwardsiella tarda with minimal inhibit concentration (MIC) value of 4 μg/mL.

中文翻译：

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Thiocladospolides FJ，含有来自红树林内生真菌 Cladosporium oxysporum HDN13-314 的 12 元大环内酯类的抗菌硫磺

五个未描述的 12 元大环内酯含有硫醚、 thiocladospolides FJ，连同已知的生物遗传相关类似物，是从红树林衍生的内生真菌 Cladosporium oxysporum 中分离出来的。通过单晶 X 射线衍射推导了硫克拉多酯 F 的绝对构型，而硫克拉多酯 GJ 的绝对构型是基于比旋光度和电子圆二色性 (ECD) 数据以及生物遗传考虑确定的。Thiocladospolide G 对水生病原体 Edwardsiella tarda 具有最佳抗菌活性，最小抑制浓度 (MIC) 值为 4 μg/mL。