Ten undescribed alkaloids, named integerrines A-J, including one racemic heterodimer of carbazole and indole, two racemic, two scalemic, and one enantiomerically enriched biscarbazoles, two aldoximes, and one racemic pyrrolone, were isolated from the dried leaves and stems of Micromelum integerrimum. The racemic or scalemic compounds were resolved using chiral-phase HPLC and their configurations were determined by comparison of experimental and calculated ECD data. Four compounds exhibited moderate to weak cytotoxicities against HepG2, HTC-116, HeLa, and PANC-1 cell lines, with IC50 values of 14.1-67.5 μM.

中文翻译：

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小蜜瓜细胞毒性生物碱的分离与结构表征

从 Micromelum integerrimum 的干燥叶和茎中分离出 10 种未描述的生物碱，命名为 integerrines AJ，包括咔唑和吲哚的一种外消旋异二聚体、两种外消旋、两种缩放和一种富含对映体的双咔唑、两种醛肟和一种外消旋吡咯酮。使用手性相 HPLC 解析外消旋或缩放化合物，并通过比较实验和计算的 ECD 数据确定它们的构型。四种化合物对 HepG2、HTC-116、HeLa 和 PANC-1 细胞系表现出中到弱的细胞毒性，IC50 值为 14.1-67.5 μM。