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Chemokines in bone-metastatic breast cancer: Therapeutic opportunities.
International Immunopharmacology ( IF 5.6 ) Pub Date : 2020-07-22 , DOI: 10.1016/j.intimp.2020.106815
Yucheng Wang 1 , Shihong Ren 2 , Zhan Wang 3 , Zenan Wang 3 , Ning Zhu 1 , Danyang Cai 1 , Zhaoming Ye 3 , Jianwei Ruan 4
Affiliation  

Due to non-response to chemotherapy, incomplete surgical resection, and resistance to checkpoint inhibitors, breast cancer with bone metastasis is notoriously difficult to cure. Therefore, the development of novel, efficient strategies to tackle bone metastasis of breast cancer is urgently needed. Chemokines, which induce directed migration of immune cells and act as guide molecules between diverse cells and tissues, are small proteins indispensable in immunity. These complex chemokine networks play pro-tumor roles or anti-tumor roles when produced by breast cancer cells in the tumor microenvironment. Additionally, chemokines have diverse roles when secreted by various immune cells in the tumor microenvironment of breast cancer, which can be roughly divided into immunosuppressive effects and immunostimulatory effects. Recently, targeting chemokine networks has been shown to have potential for use in treatment of metastatic malignancies, including bone-metastatic breast cancer. In this review, we focus on the role of chemokines networks in the biology of breast cancer and metastasis to the bone. We also discuss the therapeutic opportunities and future prospects of targeting chemokine networks, in combination with other current standard therapies, for the treatment of bone-metastatic breast cancer.



中文翻译:

骨转移性乳腺癌中的趋化因子:治疗机会。

由于对化学疗法无反应,手术切除不完全以及对检查点抑制剂的抵抗力,众所周知,具有骨转移的乳腺癌很难治愈。因此,迫切需要开发新颖,有效的策略来解决乳腺癌的骨转移。趋化因子是诱导免疫细胞定向迁移并在多种细胞和组织之间充当指导分子的物质,是免疫力中不可或缺的小蛋白。当由乳腺癌细胞在肿瘤微环境中产生时,这些复杂的趋化因子网络起着促肿瘤作用或抗肿瘤作用。另外,趋化因子在乳腺癌的肿瘤微环境中被各种免疫细胞分泌时具有多种作用,大致可分为免疫抑制作用和免疫刺激作用。最近,靶向趋化因子网络已被证明具有用于治疗包括骨转移性乳腺癌在内的转移性恶性肿瘤的潜力。在这篇综述中,我们关注趋化因子网络在乳腺癌生物学和骨转移生物学中的作用。我们还将讨论靶向趋化因子网络的治疗机会和与其他当前标准疗法相结合的治疗骨转移性乳腺癌的未来前景。

更新日期:2020-07-22
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