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Development of in vitro 2D and 3D microelectrode arrays and their role in advancing biomedical research
Journal of Micromechanics and Microengineering ( IF 2.3 ) Pub Date : 2020-07-20 , DOI: 10.1088/1361-6439/ab8e91
Charles M Didier 1, 2 , Avra Kundu 1 , David DeRoo 1 , Swaminathan Rajaraman 1, 2, 3, 4
Affiliation  

The development of microelectrode arrays (MEAs) along with complementary advances in electronics, mechanics and software to connect with these arrays has led to the in vitro interfacing and benchtop electrophysiological models of several electrically active cells such as neurons and cardiomyocytes proving vital models and testing of human disease conditions in a dish/on a chip. This topical review deals with the micro/nanofabrication technology development of Microelectrodes Arrays from early silicon based developments to today’s additive manufacturing technologies that have been employed to address bio-micro-electro-mechanical systems tool development in this space. Specifically 2D and 3D MEAs technologies have been reviewed in this paper along with a broad overview of some of the biological applications using these devices that are advancing the very state of biomedical research.

中文翻译:

体外2D和3D微电极阵列的开发及其在推进生物医学研究中的作用

微电极阵列(MEA)的发展,以及与这些阵列相连的电子,力学和软件的互补发展,已经导致了几种电活性细胞(如神经元和心肌细胞)的体外接口和台式电生理模型,证明了重要的模型和测试菜肴/芯片上的人类疾病状况。这篇专题回顾涉及微电极阵列的微/纳米加工技术发展,从早期的硅基开发到如今的增材制造技术,这些技术已被用来解决这一领域中的生物微机电系统工具开发问题。
更新日期:2020-07-21
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