The vertebral laminar defects caused by severe spina bifida occulta, spinal fracture, or bone tuberculosis require surgical treatment. The reconstruction of vertebral laminar defects remains challenging, especially in children. In this study, we created an animal model of vertebral laminar defects in newly weaned rabbits to evaluate the therapeutic effect of bovine bone collagen particle (BBCP) that combined with bone morphogenetic protein-2 with collagen binding domain (CBD-BMP-2). The tissues at the injury site which were harvested after 12 weeks indicated that newly formed bone was observed in both BBCP and BBCP/CBD-BMP-2 groups, whereas the injury site of the control group was mostly filled by fibrous tissue. The BBCP/CBD-BMP-2 group recovered better than the BBCP group. These findings indicate that a combination of BBCP with CBD-BMP-2 may be a good strategy for vertebral laminar defects in children.

由严重的隐匿性脊柱裂、脊柱骨折或骨结核引起的椎板缺损需要手术治疗。椎板缺损的重建仍然具有挑战性，尤其是在儿童中。在这项研究中，我们创建了一个新断奶兔椎板缺损动物模型，以评估牛骨胶原蛋白颗粒（BBCP）与骨形态发生蛋白-2与胶原蛋白结合域（CBD-BMP-2）结合的治疗效果。12周后采集的损伤部位组织表明，BBCP和BBCP/CBD-BMP-2组均观察到新形成的骨，而对照组的损伤部位主要由纤维组织填充。BBCP/CBD-BMP-2 组比 BBCP 组恢复得更好。