Cephalalgia ( IF 4.9 ) Pub Date : 2020-07-20 , DOI: 10.1177/0333102420941115 Håkan Ashina 1 , Haidar Muhsen Al-Khazali 1 , Afrim Iljazi 1 , Sait Ashina 2, 3, 4 , Niklas Rye Jørgensen 5 , Faisal Mohammad Amin 1 , Messoud Ashina 1 , Henrik Winther Schytz 1
Objective
To investigate the role of calcitonin gene-related peptide (CGRP) in persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI).
Methods
A total of 100 individuals with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls were enrolled between July 2018 and June 2019. Blood was drawn from the antecubital vein and subsequently analyzed using a validated radioimmunoassay for human CGRP. Measurements were performed on coded samples by a board-certified laboratory technician who was blind to clinical information.
Results
CGRP plasma levels were lower in subjects with persistent PTH (mean, 75.8 pmol/L; SD, 26.4 pmol/L), compared with age- and gender-matched healthy controls (mean, 88.0 pmol/L; SD, 34.1 pmol/L) (p = 0.04). No correlation was found of CGRP plasma levels with monthly headache days (r = −0.11; p = 0.27), monthly migraine-like days (r = 0.15; p = 0.13), headache quality (r = −0.14; p = 0.15), or a chronic migraine-like headache phenotype (r = −0.02; p = 0.85).
Conclusions
CGRP plasma measurements are unlikely a feasible blood-based biomarker of persistent PTH. Future studies should assess whether CGRP plasma measurements can be used to predict development of persistent PTH.
中文翻译:
轻度创伤性脑损伤导致的持续性外伤后头痛中降钙素基因相关肽的血浆水平低。
客观的
研究降钙素基因相关肽(CGRP)在轻度创伤性脑损伤(TBI)所致持续性外伤后头痛(PTH)中的作用。
方法
2018 年 7 月至 2019 年 6 月期间,共有 100 名因轻度 TBI 患有持续性 PTH 的个体和 100 名年龄和性别匹配的健康对照被招募。从肘前静脉抽取血液,随后使用经验证的人 CGRP 放射免疫分析进行分析。由一名对临床信息视而不见的获得委员会认证的实验室技术人员对编码样本进行了测量。
结果
与年龄和性别匹配的健康对照(平均,88.0 pmol/L;SD,34.1 pmol/L)相比,持续性 PTH 受试者的 CGRP 血浆水平较低(平均,75.8 pmol/L;SD,26.4 pmol/L) ) ( p = 0.04)。未发现 CGRP 血浆水平与每月头痛天数 ( r = -0.11; p = 0.27)、每月偏头痛样天数 ( r = 0.15; p = 0.13)、头痛质量 ( r = -0.14; p = 0.15) 之间存在相关性,或慢性偏头痛样头痛表型(r = -0.02;p = 0.85)。
结论
CGRP 血浆测量不太可能是持续性 PTH 的可行的基于血液的生物标志物。未来的研究应评估 CGRP 血浆测量值是否可用于预测持续性 PTH 的发展。