Purpose. This study is aimed at investigating the relationship between red cell distribution width (RDW) and chronic obstructive pulmonary disease (COPD) patients with pulmonary embolism (PE). Methods. We conducted a retrospective study enrolling a total of 125 patients from January 2013 to December 2019. The study group consisted of 40 COPD patients with PE, and the control group had 85 COPD patients without PE. Clinical data including demographic characteristics, comorbidities, and results of imaging examinations and laboratory tests were recorded. Blood biomarkers, including red blood cell distribution width standard deviation (RDW-SD), red blood cell distribution width coefficient of variation (RDW-CV), and D-Dimer, were included. Results. RDW-SD and RDW-CV were higher in the COPD patients with the PE group (). A higher RDW-SD led to a significantly increased risk of PE than a lower RDW-SD (adjusted odds ratio (OR): 1.188; 95% confidence interval (CI): 1.048-1.348). The area under the curve (AUC) of RDW-SD used for predicting PE was 0.737. Using 44.55 as the cutoff value of RDW-SD, the sensitivity was 80% and the specificity was 64.7%. The prediction accuracy of RDW-SD combined with D-Dimer () was higher than that of RDW-SD or D-Dimer alone. The optimal cutoff value of RDW-SD+D-Dimer for predicting PE was 0.266, which generated a sensitivity of 87.5% and specificity of 83.5%. Conclusion. RDW is significantly increased in COPD patients with PE and may thus be useful in predicting the occurrence of PE in patients with COPD.

中文翻译：

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慢性阻塞性肺疾病肺栓塞患者红细胞分布宽度的预测价值。

目的。本研究旨在调查红细胞分布宽度（RDW）与慢性阻塞性肺病（COPD）合并肺栓塞（PE）患者的关系。方法。我们于 2013 年 1 月至 2019 年 12 月进行了一项回顾性研究，共纳入 125 名患者。研究组包括 40 名合并肺栓塞的慢性阻塞性肺病患者，对照组有 85 名没有肺栓塞的慢性阻塞性肺病患者。记录临床数据，包括人口统计学特征、合并症、影像学检查和实验室检查结果。包括红细胞分布宽度标准差（RDW-SD）、红细胞分布宽度变异系数（RDW-CV）和D-二聚体等血液生物标志物。结果. 与 PE 组相比，COPD 患者的 RDW-SD 和 RDW-CV 更高（）。与较低的 RDW-SD 相比，较高的 RDW-SD 导致 PE 风险显着增加（调整优势比 (OR)：1.188；95% 置信区间 (CI)：1.048-1.348）。用于预测 PE 的 RDW-SD 曲线下面积 (AUC) 为 0.737。以44.55作为RDW-SD的临界值，敏感性为80%，特异性为64.7%。RDW-SD结合D-Dimer的预测精度（)高于单独使用 RDW-SD 或 D-二聚体。RDW-SD+D-二聚体预测PE的最佳截断值为0.266，其敏感性为87.5%，特异性为83.5%。结论。RDW 在伴有 PE 的 COPD 患者中显着增加，因此可能有助于预测 COPD 患者 PE 的发生。