Abstract

Purpose

The quality assurance guidelines of the European Society for Hyperthermic Oncology (ESHO) specify the requirements for appropriate superficial heating using phantoms. In this current piglet study, we have examined these requirements under in vivo conditions.

Materials and Methods

The evaluation is based on simultaneous, invasive temperature measurements at 8 different depths between 2 and 20 mm in the thigh of anesthetized piglets during irradiation with water-filtered infrared radiation (wIRA). Temperature probes were equally distributed in an area of 10 cm diameter of homogeneously irradiated skin. Piglets were irradiated to 126.5 mW cm⁻² in the spectral range of IR-A.

Results

Heating rates and specific absorption rates were in full accordance with the ESHO standards. Due to early onset of thermoregulation, the desired temperature rise of 6 K at a depth of 5 mm was achieved after about 10 min of exposure, i.e. 4 min later than required for phantoms. After reaching thermal steady state, on average T ₉₀ ≥ 40 °C occurred in tissue depths up to 20 mm, T ₅₀ ≥ 41 °C up to 16 mm, and a mean CEM₄₃ T ₉₀ ≈ 1 min was calculated for depths up to 8 mm.

Conclusions

Piglet data are comparable with preliminary literature data assessed in vivo in the abdominal wall and in recurrent breast cancer of humans. The potential of wIRA-HT for adequate treatment of superficial tissues/cancers in the clinical setting thus is confirmed. To ensure therapeutically needed doses of wIRA-HT, irradiation times should be extended.

中文翻译：

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体内对仔猪皮肤和皮下组织进行wIRA加热：证明符合ESHO浅表热疗标准。

摘要

目的

欧洲高温肿瘤学会（ESHO）的质量保证指南规定了使用幻像进行适当的浅层加热的要求。在当前的仔猪研究中，我们已经在体内条件下检查了这些要求。

材料和方法

该评估是基于在经过水过滤的红外辐射（wIRA）照射期间，在麻醉小猪大腿上8个不同深度（介于2到20毫米之间）同时进行的有创温度测量。温度探头均匀分布在直径10厘米的均匀辐照皮肤区域中。在IR-A的光谱范围内，将小猪辐照至126.5mW cm ^-2。

结果

加热速率和比吸收速率完全符合ESHO标准。由于温度调节的提早开始，在暴露约10分钟后（即比幻影需要晚4分钟），在5毫米深度处实现了6 K的所需温度上升。达到平均热稳定状态时，后Ť ₉₀ ≥40℃发生在组织深度至多20mm，Ť ₅₀ ≥41°C达16毫米，且平均CEM ₄₃ Ť ₉₀计算了深度达≈1分钟8毫米

结论

仔猪数据与在人的腹壁和复发性乳腺癌中体内评估的初步文献数据相当。因此，证实了在临床环境中wIRA-HT对浅表组织/癌症进行充分治疗的潜力。为确保治疗所需的wIRA-HT剂量，应延长照射时间。