Introduction

Allergies affect 20-30% of the population and respiratory allergies are mostly due to pollen grains from anemophilous plants. One to 5% of people suffer from food allergies and clinicians report increasing numbers of pollen-food allergy syndrome (PFAS), such that the symptoms have broadened from respiratory to gastrointestinal, and even to anaphylactic shock in the presence of cofactors. Thirty to 60% of food allergies are associated with pollen allergy while the percentage of pollen allergies associated to food allergy varies according to local environment and dietary habits

Areas covered

Articles published in peer-reviewed journals, covered by PubMed databank, clinical data are discussed including symptoms, diagnosis, and management. A chapter emphasizes the role of six well-known allergen families involved in PFAS: PR10 proteins, profilins, lipid transfer proteins, thaumatin-like proteins, isoflavone reductases, and β-1,3 glucanases. The relevance in PFAS of three supplementary allergen families is presented: oleosins, polygalacturonases, and gibberellin-regulated proteins. To support the discussion a few original relevant results were added.

Expert opinion

Both allergenic sources, pollen and food, are submitted to the same stressful environmental changes resulting in an increase of pathogenesis-related proteins in which numerous allergens are found. This might be responsible for the potential increase of PFAS.

中文翻译：

---

花粉-食物过敏综合征的最新进展。

简介

过敏症影响 20-30% 的人口，呼吸道过敏症主要是由于来自风媒植物的花粉粒。1% 到 5% 的人患有食物过敏，临床医生报告说，花粉-食物过敏综合征 (PFAS) 的数量越来越多，以至于症状从呼吸道扩大到胃肠道，甚至在存在辅助因子的情况下出现过敏性休克。30% 至 60% 的食物过敏与花粉过敏有关，而与食物过敏有关的花粉过敏百分比因当地环境和饮食习惯而异

覆盖区域

发表在同行评审期刊上的文章，由 PubMed 数据库涵盖，讨论临床数据，包括症状、诊断和管理。有一章强调了与 PFAS 相关的六个众所周知的过敏原家族的作用：PR10 蛋白、profilins、脂质转移蛋白、类奇异果甜蛋白、异黄酮还原酶和 β-1,3 葡聚糖酶。介绍了三个补充过敏原家族在 PFAS 中的相关性：油质蛋白、多聚半乳糖醛酸酶和赤霉素调节蛋白。为了支持讨论，添加了一些原始的相关结果。

专家意见

过敏源，花粉和食物，都受到相同的压力环境变化的影响，导致发病机制相关蛋白质的增加，其中发现了许多过敏原。这可能是 PFAS 潜在增加的原因。