Clary sage (Salvia sclarea) is a xerophytic biennial plant typical for the Mediterranean region. It is cultivated for its essential oil, which is widely used in the flavor and fragrance industry as well as in aromatherapy for its relaxing and immunomodulatory effect. In this pilot investigation, clary sage essential oil was analyzed by GC-MS as well as GC-FID and examined regarding its effects on pulse, blood pressure and mood in healthy human female and male subjects. Analysis of the used CSEO identified linalylacetat (61.3%) and linalool (22.1%) as main compounds. Sclareol was found at 0.3%. In the first experiment with 30 participants (with 15 female), CSEO, diluted in peanut oil, was administered to the left forearm, leading to an increase in pulse rate in women (peanut oil served as control). In men, pulse rate deceased over time (p = 0.013). In the second experiment (32 participants; 16 females) the oil was inhaled for 30 min (pure water as control). The observed decrease of pulse rate was significantly stronger in women than in men (p = 0.026). To evaluate the influence of the mode of application, a comparison of both experiments was performed showing a significant difference between sexes for the parameter of pulse rate (p = 0.034). Overall, the effects elicited by CSEO may depend on application method (inhaled/dermal) and sex (male/female).

中文翻译：

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快乐鼠尾草精油及其对人类情绪和脉搏的影响：一项体内试验研究

鼠尾草（Salvia sclarea）是地中海地区典型的旱生二年生植物。它因其精油而种植，因其具有放松和免疫调节作用而广泛用于香精香料行业以及芳香疗法。在这项初步调查中，通过 GC-MS 和 GC-FID 分析了快乐鼠尾草精油，并检查了其对健康人类女性和男性受试者脉搏、血压和情绪的影响。对所用 CSEO 的分析确定芳樟醇 (61.3%) 和芳樟醇 (22.1%) 是主要化合物。香紫苏醇的含量为 0.3%。在 30 名参与者（其中 15 名女性）的第一个实验中，将用花生油稀释的 CSEO 施用于左前臂，导致女性脉搏率增加（花生油作为对照）。在男性中，脉搏率随着时间的推移而降低（p = 0.013）。在第二个实验中（32 名参与者；16 名女性）吸入油 30 分钟（纯水作为对照）。观察到的女性脉率下降明显强于男性（p = 0.026）。为了评估应用模式的影响，对两个实验进行了比较，显示了两性之间脉率参数的显着差异（p = 0.034）。总体而言，CSEO 产生的效果可能取决于应用方法（吸入/皮肤）和性别（男性/女性）。对两个实验进行了比较，显示了两性之间脉率参数的显着差异（p = 0.034）。总体而言，CSEO 产生的效果可能取决于应用方法（吸入/皮肤）和性别（男性/女性）。对两个实验进行了比较，显示了两性之间脉率参数的显着差异（p = 0.034）。总体而言，CSEO 产生的效果可能取决于应用方法（吸入/皮肤）和性别（男性/女性）。