The thymic microenvironment plays an important role in the development of T cells. A decrease of thymic epithelial cells is the main cause of age‐related thymic atrophy or degeneration. Resveratrol (RSV), a phytoalexin produced from plants, has been shown to inhibit the adverse effects of dietary obesity on the structure and function of the thymus. D‐Galactose (D‐gal) can induce accelerated aging in mice. In the present study, young mice (2 months old) were injected with D‐gal (120 mg/kg/day) for 8 consecutive weeks to construct an accelerated aging model. Compared with normal control mice, the thymus epithelium of the D‐gal treated mice had structural changes, the number of senescent cells increased, the number of CD4+ T cells decreased, and CD8+ T cells increased. After RSV administration by gavage for 6 weeks, it was found that RSV improved the surface phenotypes of D‐gal treated mice, and recovered thymus function by maintaining the ratio of CD4+ to CD8+ cells. It also indicated that RSV enhanced the cell proliferation and inhibited cell senescence. Increased autoimmune regulator (Aire) expression was present in the RSV treated mice. The lymphotoxin‐beta receptor (LTβR) expression also increased. These findings suggested that RSV intake could restore the alterations caused by D‐gal treatment in the thymus via stimulation of Aire expression.

中文翻译：

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白藜芦醇改善了D-半乳糖诱导的小鼠的胸腺衰老变化。

胸腺微环境在T细胞的发育中起重要作用。胸腺上皮细胞减少是与年龄有关的胸腺萎缩或变性的主要原因。白藜芦醇（RSV），一种植物产生的植物抗毒素，已显示出抑制饮食肥胖对胸腺结构和功能的不利影响。D-半乳糖（D-gal）可以诱导小鼠加速衰老。在本研究中，连续8周给年轻小鼠（2个月大）注射D-gal（120 mg / kg /天），以建立加速衰老模型。与正常对照小鼠相比，经D-gal处理的小鼠的胸腺上皮具有结构变化，衰老细胞数量增加，CD4 + T细胞数量减少，而CD8 + T细胞数量增加。经管饲RSV 6周后，发现RSV改善了D-gal处理的小鼠的表面表型，并通过维持CD4 +与CD8 +细胞的比例恢复了胸腺功能。还表明RSV增强了细胞增殖并抑制了细胞衰老。RSV处理的小鼠体内自身免疫调节剂（Aire）表达增加。淋巴毒素β受体（LTβR）的表达也增加。这些发现表明，摄入RSV可以通过刺激Aire表达来恢复胸腺D-gal治疗引起的改变。淋巴毒素β受体（LTβR）的表达也增加。这些发现表明，摄入RSV可以通过刺激Aire表达来恢复胸腺D-gal治疗引起的改变。淋巴毒素β受体（LTβR）的表达也增加。这些发现表明，摄入RSV可以通过刺激Aire表达来恢复胸腺D-gal治疗引起的改变。