Cytoskeletal remodeling is indispensable for the development and maintenance of neuronal structures and functions. However, the molecular machinery that controls the balance between actin polymerization and depolymerization during these processes is incompletely understood. Here, we report that coronin 2B, a conserved actin‐binding protein, is concentrated at the tips of developing dendrites and that knockdown of coronin 2B inhibits the growth of dendrites. Importantly, coronin 2B interacts with actin and reduces the F‐actin/G‐actin ratio. Furthermore, the coiled‐coil domain of coronin 2B is required for its oligomerization, thus confining coronin 2B to neurite tips. Our findings collectively suggest that coronin 2B is important for promoting dendrite outgrowth by limiting the speed of actin polymerization at growth cones.

中文翻译：

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Coronin 2B 通过调节肌动蛋白动力学来调节树突生长

细胞骨架重塑对于神经元结构和功能的发展和维持是必不可少的。然而，在这些过程中控制肌动蛋白聚合和解聚之间平衡的分子机制尚不完全清楚。在这里，我们报告了 coronin 2B，一种保守的肌动蛋白结合蛋白，集中在发育中的树突的尖端，并且 coronin 2B 的敲低抑制了树突的生长。重要的是，coronin 2B 与肌动蛋白相互作用并降低 F-肌动蛋白/G-肌动蛋白的比率。此外，coronin 2B 的卷曲螺旋结构域是其寡聚化所必需的，因此将 coronin 2B 限制在神经突尖端。我们的研究结果共同表明，coronin 2B 通过限制生长锥中肌动蛋白聚合的速度，对促进枝晶生长很重要。