Herein, we report a catalytic system based on the earth‐abundant manganese for the ketone, amine, alkyne (KA²) reaction. The efficiency of manganese manifests at relatively high temperatures, combined with sustainable reaction conditions, and provides a tool for accessing propargylamines from structurally diverse starting materials, including synthetically relevant and bioactive molecules. Our efforts were also aimed at shedding light on the catalytic mode of action of manganese in this transformation, in order to explain its temperature‐related behavior. The use of computational methods reveals mechanistic aspects of this reaction indicating important points regarding the reactivity of both manganese and ketones.

中文翻译：

---

四取代的丙炔胺的锰催化多组分合成：系统开发与理论研究

本文中，我们报告了一种基于富稀土锰的催化体系，用于酮，胺，炔烃（KA ²）反应。锰的效率在相对较高的温度下表现出来，并伴有可持续的反应条件，并提供了一种从结构多样的起始原料（包括合成相关的生物活性分子）中获取炔丙基胺的工具。我们的工作还旨在阐明锰在该转化过程中的催化作用方式，以解释其与温度有关的行为。计算方法的使用揭示了该反应的机理方面，表明了有关锰和酮的反应性的要点。