Long non-coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non-coding zinc finger E-box binding homeobox 2 antisense RNA1 (lnZEB2-AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2-AS1 can lead to tumorigenesis and cancer progression. lncZEB2-AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2-AS1 in cells and its function in cancer progression.

中文翻译：

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lncRNA ZEB2-AS1：人类癌症的一种有前途的生物标志物

长链非编码 RNA (lncRNA) 是转录长度超过 200 nt 且不会翻译成蛋白质的 ncRNA 之一。研究表明，lncRNAs 在人类疾病尤其是癌症中具有调节功能。lncRNA 功能障碍会导致细胞行为改变，包括增殖、侵袭和迁移，还可以抑制细胞凋亡。长链非编码锌指 E-box 结合同源框 2 反义 RNA1 (lnZEB2-AS1) 是在不同癌症中发挥致癌作用的 lncRNA 之一。lncZEB2-AS1 的失调可导致肿瘤发生和癌症进展。lncZEB2-AS1 可以作为人类癌症的诊断标志物或治疗靶点引入。在这篇综述中，我们简要描述了 ZEB2-AS1 在细胞中的作用机制及其在癌症进展中的作用。