当前位置: X-MOL 学术Am. J. Reprod. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The chimera-type galectin-3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus.
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2020-07-21 , DOI: 10.1111/aji.13311
Nancy Freitag 1, 2 , Irene Tirado-González 1 , Gabriela Barrientos 3 , Marie Cohen 4 , Silvia Daher 5 , Debra Goldman-Wohl 6 , Lucia Mincheva-Nilsson 7 , Constance M John 8 , Udo Jeschke 9 , Sandra M Blois 1, 10
Affiliation  

From conception, a delicate regulation of galectins, a family of carbohydrate‐binding proteins, is established to ensure maternal immune tolerance in pregnancy. Though galectin‐3 (gal‐3), the only chimera‐type galectin, is abundantly expressed at the feto‐maternal interface; the physiological role of this lectin during pregnancy remains to be fully elucidated and requires further investigation.

中文翻译:

嵌合型 galectin-3 是滋养层功能的正调节剂,在妊娠期糖尿病中表达失调。

从受孕开始,就建立了对半乳糖凝集素(一个碳水化合物结合蛋白家族)的微妙调节,以确保母体在怀孕期间的免疫耐受性。尽管 galectin-3 (gal-3) 是唯一的嵌合型半乳糖凝集素,但在胎儿-母体界面大量表达;这种凝集素在怀孕期间的生理作用仍有待充分阐明,需要进一步研究。
更新日期:2020-07-21
down
wechat
bug