Ultrasound (US)‐triggered sonodynamic therapy (SDT) can significantly solve the problem of tissue penetrability of light of photodynamic therapy (PDT) that has long vexed physicians in clinics. However, there is a great shortage of sonosensitizers for SDT. Currently, several photosensitizers and their derivatives have been reported for SDT but these dyes are usually quenched when aggregated due to aggregation‐caused quenching (ACQ) effect. In this work, aggregation‐induced emission (AIE) dye (TTMN) assembled nanoparticles (S‐AIE) are synthesized and employed as sonosensitizers for enhanced SDT due to the unique properties of the AIE dye and the deep tissue penetration of ultrasound. Results show that S‐AIE can generate potent singlet oxygen (¹O₂) under US irradiation to induce cancer cells apoptosis and clearly inhibit tumor growth in vitro and in vivo. In particular, the intrinsic fluorescence of AIE dye can guide the procedure of SDT. To the best of current knowledge, this is the first demonstration of AIE dyes being used as sonosensitizers for SDT and importantly, this work could inspire other more efficient AIE dyes for being used as sonosensitizers for SDT of deep‐seated tumors.

中文翻译：

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超声激发聚集诱导发射染料可增强肿瘤声波动力疗法

超声波（US）触发的声动力学疗法（SDT）可以显着解决光动力学疗法（PDT）的组织穿透性问题，这种现象长期困扰着临床医生。但是，SDT的声敏剂非常短缺。目前，已经报道了几种光敏剂及其衍生物用于SDT，但是由于聚集引起的猝灭（ACQ）效应，这些染料在聚集时通常会被猝灭。在这项工作中，由于AIE染料的独特性质和超声的深层组织穿透作用，合成了聚集诱导发射（AIE）染料（TTMN）组装的纳米颗粒（S-AIE），并用作增强SDT的声敏剂。结果表明S‐AIE可以产生有效的单线态氧（¹ O ₂）在US辐射下诱导癌细胞凋亡并明显抑制体内外肿瘤的生长。特别是，AIE染料的固有荧光可以指导SDT的操作。就目前所知，这是首次证明AIE染料可用作SDT的声敏剂，并且重要的是，这项工作可以启发其他更有效的AIE染料用作深部肿瘤的SDT的声敏剂。