Since borosilicate bioactive glass (BBG) is famous for its degradation, biocompatibility and osteogenesis, and the whitlockite (WH: Ca₁₈Mg₂(HPO₄)₂(PO₄)₁₂) is one of the main components of inorganic phase of bone which plays an important role in bone growth, herein, we have firstly designed a novel bone cement by incorporating WH with BBG (BBG/WH). Results indicated that the addition of WH had significantly enhanced the cohesiveness of bone cement. Furthermore, the mechanism of the incorporation of WH in BBG had also been investigated that the cross link, Van der Waals force and WH/sodium alginate interaction has worked in the BBG/WH. Additionally, the BBG/WH bone cement exhibited excellent mineralization ability in vitro with continuously released Ca²⁺ and Mg²⁺ when immersed in simulated body fluid (SBF). Particularly, BBG4:WH2 bone cement had the best cell proliferation and osteogenic differentiation performance compared with other groups when cultured with rat bone marrow mesenchymal stem cells (rBMSCs).

由于硼硅酸盐生物活性玻璃（BBG）以其降解，生物相容性和成骨作用以及菱镁矿（WH：Ca ₁₈ Mg ₂（HPO ₄）₂（PO ₄）₁₂）而闻名。）是骨的无机相的主要成分之一，在骨骼的生长中起着重要的作用。在此，我们首先通过将WH与BBG（BBG / WH）结合来设计一种新型的骨水泥。结果表明，加入WH可以显着增强骨水泥的内聚性。此外，还研究了WH掺入BBG中的机理，表明交联，范德华力和WH /藻酸钠相互作用在BBG / WH中起作用。此外，BBG / WH骨水泥在体外具有优异的矿化能力，并持续释放Ca ²⁺和Mg ²⁺当浸入模拟体液（SBF）中时。特别地，当用大鼠骨髓间充质干细胞（rBMSCs）培养时，BBG4：WH2骨水泥与其他组相比具有最佳的细胞增殖和成骨分化性能。