The anti-lung cancer activity of oligosaccharides derived from glucuronomannan was investigated. The inhibition of A549 cell proliferation by glucuronomannan (Gn) and its oligomers (dimer (G2), tetramer (G4) and hexamer (G6)) were concentration dependent. In vivo activities on the A549-derived tumor xenografts showed the tumor inhibition of G2, G4 and G6 were 17 %, 40 % and 46 %, respectively. Organ coefficients in nude mice showed an increase in the kidney with G4, the brain with G6, and the spleen with G6. An advanced tandem mass tag labeled proteomics approach was performed. A significant differential expression was found in 59 out of the 4371 proteins, which involved the immune system. Surface plasmon resonance (SPR) studies revealed G6 was strongly bound to immunoglobulin G. This suggests that glucuronomannan hexamer inhibits the proliferation of lung cancer through its binding to immunoglobulin.

研究了葡糖醛酸甘露聚糖的寡糖的抗肺癌活性。葡糖醛酸甘露聚糖（Gn）及其寡聚体（二聚体（G2），四聚体（G4）和六聚体（G6））对A549细胞增殖的抑制是浓度依赖性的。体内对来自A549的肿瘤异种移植物的活性显示，对G2，G4和G6的肿瘤抑制分别为17％，40％和46％。裸鼠的器官系数显示，G4肾脏增加，G6大脑增加，G6脾增加。进行了先进的串联质量标签标记的蛋白质组学方法。在涉及免疫系统的4371种蛋白质中，有59种存在显着差异表达。表面等离子体共振（SPR）研究表明，G6与免疫球蛋白G牢固结合。这表明葡糖醛酸甘露聚糖六聚体通过与免疫球蛋白结合而抑制肺癌的增殖。