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TLPdb: A Resource for Thaumatin-Like Proteins.
The Protein Journal ( IF 3 ) Pub Date : 2020-07-21 , DOI: 10.1007/s10930-020-09909-w
Chandana Thimme Gowda 1 , Siva Naga Suresh Purama 2 , Rajagopal Kammara 1, 3
Affiliation  

Antifungal proteins and peptides have drawn the attention of numerous plant biologists and Clinicians, owing to their potential value in protecting commercial crops as well as preventing fungal infections in humans. Various proteins and peptides, such as glucanases, chitinases, chitinase-like proteins, lectins, peroxidases, defensins, and lipid transfer proteins have antifungal activities. Thaumatin is a protein from a West African plant Thaumatococcus danielli that is sweet in taste but does not exhibit antifungal activities. Despite the structural similarities between thaumatins and thaumatin-like proteins (TLPs), TLPs are not sweet in taste, unlike thaumatins. We developed a thaumatin-like protein database of various organisms. TLPs are pathogenesis-related proteins (PR) with molecular masses of 20–26 kDa. The amino acid residues of TLPs involved in an antifungal activity remain obscure and make it hard to receive comprehensive information on TLPs. The biggest problem in the wine industry is white haze, an undesirable feature of high-quality wine. Hence, the problem may be figured out with the easy accessibility of amino acid sequences and to generate infest resistant crops. Overall, we aimed to produce a freely accessible TLP database (https://tlpdb.cftri.com) that would provide substantive information in understanding the mechanistic facet of TLPs. Briefly, TLPdb contains sequences, structures, and amino acid compositions of validated, published TLP protein sequences (from the plant, fungal as well as animal sources). Thus, this work may yield valuable information that may be useful in understanding the mechanistic aspects of TLP activity and in the evolution of antifungal proteins and fungal resistant crops. TLPdb is a comprehensive thaumatin-like protein resource database of various organisms. The database can serve as a unique Bioinformatics tool for understanding the TLPs. This further may help in understanding and the development of fungal resistant crops. TLPdb is freely available at https://tlpdb.cftri.com.

中文翻译:

TLPdb:一种类似Thaumatin的蛋白质资源。

抗真菌蛋白和肽由于其在保护商业作物以及预防人类真菌感染方面的潜在价值,已经引起了众多植物生物学家和临床医生的关注。各种蛋白质和肽,例如葡聚糖酶,几丁质酶,几丁质酶样蛋白,凝集素,过氧化物酶,防御素和脂质转移蛋白均具有抗真菌活性。Thaumatin是西非植物Thaumatococcus danielli的蛋白质味甜,但不表现出抗真菌活性。尽管奇异果甜蛋白和奇异果甜蛋白类似蛋白(TLP)在结构上相似,但是与奇异果甜蛋白不同,TLP的味道并不甜。我们开发了各种生物的类索蛋白类似蛋白的数据库。TLP是与发病机理相关的蛋白质(PR),分子量为20–26 kDa。涉及抗真菌活性的TLP的氨基酸残基仍然不清楚,难以接收有关TLP的全面信息。葡萄酒行业最大的问题是白雾,这是高品质葡萄酒的不良特性。因此,可以通过容易获得氨基酸序列并产生抗病作物来解决该问题。总体而言,我们的目标是建立一个可免费访问的TLP数据库(https://tlpdb.cftri。com),这将为理解TLP的机制方面提供实质性信息。简而言之,TLPdb包含已验证的已发布TLP蛋白序列的序列,结构和氨基酸组成(来自植物,真菌和动物)。因此,这项工作可能会产生有价值的信息,这些信息可能有助于理解TLP活性的机制方面以及抗真菌蛋白和抗真菌农作物的进化。TLPdb是各种生物的全面的类索马汀蛋白资源数据库。该数据库可以用作了解TLP的独特生物信息学工具。这可以进一步帮助理解和发展抗真菌作物。TLPdb可从https://tlpdb.cftri.com免费获得。验证的,已发表的TLP蛋白序列的结构,氨基酸组成(来自植物,真菌和动物)。因此,这项工作可能会产生有价值的信息,这些信息可能有助于理解TLP活性的机制方面以及抗真菌蛋白和抗真菌农作物的进化。TLPdb是各种生物的全面的类索马汀蛋白资源数据库。该数据库可以用作了解TLP的独特生物信息学工具。这可以进一步帮助理解和发展抗真菌作物。TLPdb可从https://tlpdb.cftri.com免费获得。验证的,已发布的TLP蛋白序列的结构,氨基酸组成(来自植物,真菌和动物)。因此,这项工作可能会产生有价值的信息,这些信息可能有助于理解TLP活性的机制方面以及抗真菌蛋白和抗真菌农作物的进化。TLPdb是各种生物的全面的类索马汀蛋白资源数据库。该数据库可以用作了解TLP的独特生物信息学工具。这可以进一步帮助理解和发展抗真菌作物。TLPdb可从https://tlpdb.cftri.com免费获得。这项工作可能会产生有价值的信息,这些信息可能有助于理解TLP活性的机械方面以及抗真菌蛋白和抗真菌农作物的进化。TLPdb是各种生物的全面的类索马汀蛋白资源数据库。该数据库可以用作了解TLP的独特生物信息学工具。这可以进一步帮助理解和发展抗真菌作物。TLPdb可从https://tlpdb.cftri.com免费获得。这项工作可能会产生有价值的信息,这些信息可能有助于理解TLP活性的机械方面以及抗真菌蛋白和抗真菌农作物的进化。TLPdb是各种生物的全面的类索马汀蛋白资源数据库。该数据库可以用作了解TLP的独特生物信息学工具。这可以进一步帮助理解和发展抗真菌作物。TLPdb可从https://tlpdb.cftri.com免费获得。这可以进一步帮助理解和发展抗真菌作物。TLPdb可从https://tlpdb.cftri.com免费获得。这可以进一步帮助理解和发展抗真菌作物。TLPdb可从https://tlpdb.cftri.com免费获得。
更新日期:2020-07-21
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