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Assessment of reactor-produced 199Au as a promising theranostic radionuclide and subsequent separation from platinum target
Journal of Radioanalytical and Nuclear Chemistry ( IF 1.6 ) Pub Date : 2020-06-23 , DOI: 10.1007/s10967-020-07257-8
Mohamed F. Attallah , Mohamed A. Gizawy , Hesham A. Shamsel-Din , Nader M. A. Mohamed , Amal M. I. Ali

Feasibility of 199Au production from neutron activated platinum and gold targets at the Egyptian Second Research Reactor was studied. A comparison between theoretical calculations and experimental measurements for the two targets was carried out. A radiochemical separation of 199Au from irradiated Pt target was achieved using chromatographic column packed with modified chabazite material with elution efficiency of 90 ± 0.54% based on the high separation factor between Au and other produced undesired radionuclides. Three quality control tests; radionuclidic, radiochemical and chemical purities were carried out on the eluted 199Au to ensure its safe application in nuclear medicine.

中文翻译:

评估反应堆产生的 199Au 作为一种有前途的治疗诊断放射性核素并随后与铂靶分离

研究了在埃及第二研究反应堆中用中子活化铂和金靶生产 199Au 的可行性。对两个目标的理论计算和实验测量进行了比较。基于 Au 和其他产生的不需要的放射性核素之间的高分离因子,使用填充有改性菱沸石材料的色谱柱实现了 199Au 与辐照 Pt 靶的放射化学分离,洗脱效率为 90 ± 0.54%。三项质控测试;对洗脱的 199Au 进行了放射性核素、放射化学和化学纯化,以确保其在核医学中的安全应用。
更新日期:2020-06-23
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