当前位置: X-MOL 学术Int. J. Pept. Res. Ther. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Valorization of Lipopeptides Biosurfactants as Anticancer Agents
International Journal of Peptide Research and Therapeutics ( IF 2.5 ) Pub Date : 2020-07-20 , DOI: 10.1007/s10989-020-10105-8
Marian Rofeal , Fady Abd El-Malek

Biosurfactants are natural compounds produced biologically by certain bacterial strains. They are promising alternatives in several applications due to their biocompatibility, biodegradability and reduced toxicity. Systemic toxicity problems and drug resistance in tumor chemotherapy are urging the continued discovery of new antitumor agents. Biosurfactants have significant effect in inhibiting multiple tumor types. Specifically, surfactin, iturin, and fengycin lipopeptide biosurfactant were previously produced from several bacterial species belonging to Bacillus genus. Only few previous studies investigated their cytotoxicity against some tumor types such as breast, colon, leukemia, hepatoma and others. Due to the probability of being potential antitumor treatments, biosurfactants nanoparticles could be clinically recommended. This review discussed the properties of biologically-produced biosurfactants and their antitumor activities against distinctive cancer models. Additionally, it underlines their potential mechanisms and sheds light on the discovery of new active bioproducts.



中文翻译:

脂肽生物表面活性剂作为抗癌药的增值

生物表面活性剂是由某些细菌菌株生物学产生的天然化合物。由于它们的生物相容性,生物降解性和降低的毒性,它们在一些应用中是有希望的替代品。肿瘤化疗中的全身毒性问题和耐药性促使人们不断发现新的抗肿瘤药物。生物表面活性剂在抑制多种肿瘤类型方面具有显著作用。具体而言,表面活性素,iturin和丰霉素脂肽生物表面活性剂以前是从属于芽孢杆菌的几种细菌中生产的属。以前只有很少的研究调查了它们对某些类型的肿瘤(如乳腺癌,结肠癌,白血病,肝癌等)的细胞毒性。由于存在潜在的抗肿瘤治疗的可能性,因此可以在临床上推荐生物表面活性剂纳米颗粒。这篇综述讨论了生物产生的生物表面活性剂的性质及其对独特癌症模型的抗肿瘤活性。此外,它强调了它们的潜在机制,并为发现新的活性生物产品提供了启示。

更新日期:2020-07-21
down
wechat
bug