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Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island
Biotechnology and Bioprocess Engineering ( IF 3.2 ) Pub Date : 2020-07-21 , DOI: 10.1007/s12257-019-0371-4
Seul Ki Min , Jung Eun Kim , Ju-Mi Hong , Joung Han Yim , Hyun Park , Ui Joung Youn , Se Jong Han , Il-Chan Kim

Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopoly-saccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1ß and 1α (IL-6, IL-1ß and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.



中文翻译:

南极世宗大王岛采集的非洲菊提取物的抗炎作用

慢性炎症是类风湿关节炎和哮喘等各种疾病的诱因,许多人患有这些疾病。有许多报道甚至将癌症与炎症联系起来,因此继续需要开发功能强大的药物。在这里,我们证明了Lecania gerlachei的甲醇提取物(LGME)是在极端南极环境中发现的地衣成员,具有抗炎活性。用LGME处理脂多糖(LPS)刺激的Raw 264.7鼠巨噬细胞可降低一氧化氮(NO)免疫调节剂的产生,并下调诱导型一氧化氮合酶(iNOS),促炎性白介素6、1ß和1α(IL -6,IL-1ß和IL-1α,以及肿瘤坏死因子α(TNF-α)的浓度和浓度均与浓度无关。此外,发现这些作用是由核因子κB(NF-κB)信号传导抑制介导的。因此,我们的发现可能有助于新型炎症药物的开发。

更新日期:2020-07-21
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