The effect of conditions on the regularities of the two-stage one-pot synthesis of N-(dibutylaminomethyl)methacrylamide (DBAMMA) via the Mannich reaction of methacrylamide, formaldehyde and dibutylamine in a heterophase aqueous system has been studied. The conditions of the synthesis of DBAMMA with a 96% yield at 35 °C have been determined. This variant of the synthesis of hydrophobic amino-containing methacrylamide has good practical prospects because of the high yield of the target product achieved under mild conditions in aqueous medium with an equimolar ratio of the initial reagents, the absence of by-products and easy separation of the target monomer from the reaction mixture.

中文翻译：

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温和条件下曼尼希反应两步一锅法合成N-（二丁基氨基甲基）甲基丙烯酰胺

对的两阶段一锅合成的规律性条件的影响ñ - （二丁基氨基甲基）甲基丙烯酰胺（DBAMMA）通过甲基丙烯酰胺，甲醛和二丁胺在多相含水体系曼尼希反应进行了研究。确定了在35°C合成DBAMMA的产率为96％的条件。疏水性含氨基的甲基丙烯酰胺合成的这种变体具有良好的实际应用前景，因为在温和条件下在水性介质中以等摩尔比例的起始试剂可实现目标产物的高收率，不存在副产物且易于分离。反应混合物中的目标单体。