Brain PET, which has led research in molecular imaging and diagnosis of brain cancer, epilepsy and neurodegenerative disorders, is being spotlighted again to promote earlier diagnosis of dementia with the advent of amyloid and tau tracers. To meet this demand, in this paper, we developed a brain-dedicated PET imaging device with a hemispherical detector arrangement, which provides comparable sensitivity with fewer detectors than conventional cylindrical geometries. The introduction of the time-of-flight (TOF) measurement capability was a key point for the development to get a gain in the image signal-to-noise ratio. Currently, whole-body PET scanners with around 200–400 ps coincidence resolving time (CRT) are commercially available. In order to obtain the same TOF gain which can be obtained with 400 ps CRT for a 30 cm diameter object, 267 ps CRT will be required for a 20 cm diameter object such as the human head. In this work, therefore, we aimed at developing a TOF brain-dedica...

中文翻译：

---

带有半球形检测器装置的245 ps-TOF脑专用PET原型

Brain PET引领了脑癌，癫痫和神经退行性疾病的分子成像和诊断研究，随着淀粉样蛋白和tau示踪剂的出现，Brain PET再次受到关注，以促进痴呆的早期诊断。为了满足这一需求，在本文中，我们开发了一种具有半球形探测器结构的专用于大脑的PET成像设备，与传统的圆柱几何体相比，它具有更少的探测器，可提供可比的灵敏度。飞行时间（TOF）测量功能的引入是开发获得图像信噪比增益的关键点。目前，市售的重合分辨时间（CRT）约为200-400 ps的全身PET扫描仪。为了获得与直径为30 cm的物体使用400 ps CRT可获得的相同的TOF增益，对于直径为20 cm的物体（例如人头），需要267 ps的CRT。因此，在这项工作中，我们旨在开发TOF大脑专用药物。