Ferrocenyl imidazolo[2,1-b]-1,3,4-thiadiazoles are synthesized using 2-amino-5-substituted-1,3,4-thiadiazole and α-bromoacetyl ferrocene as substrates under microwave-assisted and catalyst-free conditions. The structures are characterized by infrared, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, mass spectrometry, and elemental analysis. Compared with conventional methods, the present protocol has the advantages of being rapid, efficient, environmentally friendly, and low cost. The results of biological activity studies showed that the products displayed better activities than those of 2-amino-5-substituted-1,3,4-thiadiazole. The biological activities of compounds in which R = phenyl were better than those with alkyl groups. Compounds with electron-withdrawing groups on the aryl moiety showed increased biological activities.

二茂铁咪唑并[2,1- b在微波辅助和无催化剂条件下，以2-氨基-5-取代的1,3,4-噻二唑和α-溴乙酰基二茂铁为底物合成] -1,3,4-噻二唑。该结构的特征在于红外，1H核磁共振，13C核磁共振，质谱和元素分析。与常规方法相比，本协议具有快速，高效，环境友好，成本低廉的优点。生物学活性研究的结果表明，该产物显示出比2-氨基-5-取代-1,3,4-噻二唑更好的活性。R =苯基的化合物的生物活性优于烷基的化合物。在芳基部分具有吸电子基团的化合物显示出增加的生物活性。