The nervous system and the immune system share the common ability to exert gatekeeper roles at the interfaces between internal and external environment. Although interaction between these 2 evolutionarily highly conserved systems has been recognized for long time, the investigation into the pathophysiological mechanisms underlying their crosstalk has been tackled only in recent decades. Recent work of the past years elucidated how the autonomic nervous system controls the splenic immunity recruited by hypertensive challenges. This review will focus on the neural mechanisms regulating the immune response and the role of this neuroimmune crosstalk in hypertension. In this context, the review highlights the components of the brain-spleen axis with a focus on the neuroimmune interface established in the spleen, where neural signals shape the immune response recruited to target organs of high blood pressure.

中文翻译：

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高血压免疫的神经控制：高血压委员会职业中期卓越研究奖，2019

神经系统和免疫系统具有共同的能力，可以在内部和外部环境之间的界面上发挥看门人的作用。尽管这两个进化高度保守的系统之间的相互作用早已得到认可，但对其串扰背后的病理生理机制的研究直到最近几十年才得到解决。过去几年的最新工作阐明了自主神经系统如何控制由高血压挑战招募的脾免疫。本综述将重点关注调节免疫反应的神经机制以及这种神经免疫串扰在高血压中的作用。在此背景下，该综述重点介绍了脑 - 脾轴的组成部分，重点是脾脏中建立的神经免疫界面，